Active Ingredient: Asiaticoside Herbal Plant

Asiaticoside is another active saponin, which induced type-I collagen synthesis in human dermal fibroblast cells.

Centella asiatica contains several active triterpenoids, saponins, including madecassoside, asiaticoside, centelloside, and asiatic acid, which have been reported to increase cellular hyperplasia, collagen production, granulation tissue levels of DNA, protein, total collagen, hexosamine, rapid maturation, and crosslinking of collagen [109]. Haftek et al. [110] have performed a randomized double-blind clinical trial and found significant improvement of the clinical score for wrinkles, suppleness, firmness, roughness, and skin hydration. Asiaticoside is another active saponin, which induced type-I collagen synthesis in human dermal fibroblast cells. Triterpenes including asiatic acid, madecassic acid, and asiaticoside extracted from C. asiatica were screened on human fore skin fibroblast monolayer cultures; it was observed that collagen synthesis was increased in a dose-dependent manner, whereas the specific activity of neosynthesized collagen was decreased

Asiaticoside in C. asiatica has wound curative ability by increasing angiogenesis and collagen formation. The asiaticoside enhances the stretching strength of the newly formed skin and promotes the wound’s healing. It also prevents the inflammatory process, which may increase the capillary permeability and provoke hypertrophy in abrasions (Incandela et al., 2001). In the laboratory, antioxidant levels were observed on one animal to study the effects of asiaticoside, and the antioxidants played a key role in the healing of injuries (Shukla et al., 1999). The investigator studied the effects of asiaticoside on delayed as well as normal wound healing. In studies, it was observed that topical uses of 0.2% solution of asiaticoside resulted in an increase in collagen content, 57% in tensile strength, 56% in hydroxyproline, and well epithelization in guinea pig punch wounds. But healing is delayed in streptozotocin diabetic rats, so topical application of 0.4% solution of asiaticoside on punch injuries increased tensile strength, epithelization, hydroxyproline, and collagen contents there by smoothing the healing. Oral and topical administration of an alcoholic extract of C. asiatica was studied in the laboratory. Asiaticoside was more active orally at a 1 mg/kg dose in the guinea pig punch and 40 μg/disk in chick wound. The wounds treated by extract were observed to epithelialize quicker and the speed of wound contraction was greater, as compared to the control. These results showed that C. asiatica produced different actions on the different stages of scar repair in normal as well as delayed healing models (Shukla et al., 1999).

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